P 002 Investigation of the H + / myo - inositol transporter ( HMIT ) as a neuronal regulator of phosphoinositide signalling
نویسندگان
چکیده
a neuronal regulator of phosphoinositide signalling Elena Di Daniel1, Emma Mead2, M. H. Selina Mok3, Erika Zambello4, Laura L. Caberlotto4, Theresa J. Pell1, Tim D. Werry1, Christopher J. Langmead3, Ajit J. Shah6, Christopher J. Ring2, Colin P. Glover1, Graham Duddy2, Judy Latcham5, Alastair Reith1, Ceri Davies1, James N. Kew3, Peter R. Maycox2 Synaptic Plasticity and Neural Network Dynamics DPU, Neurosciences CEDD, GlaxoSmithKline, Harlow, UK1, Discovery Technology Group, GlaxoSmithKline, Harlow, UK 2; Schizophrenia and Cognitive Disorders DPU, Neurosciences CEDD, GlaxoSmithKline, Harlow, UK3, Mood and Anxiety Disorders DPU, Neurosciences CEDD, GlaxoSmithKline, Verona, Italy4, Laboratory Animal Science GlaxoSmithKline, The Frythe, UK5, Pyschiatry CEDD, Biology,GlaxoSmithKline, Harlow, UK6
منابع مشابه
Investigation of the H(+)-myo-inositol transporter (HMIT) as a neuronal regulator of phosphoinositide signalling.
Phosphoinositide signalling regulates a series of important neuronal processes that are thought to be altered in mood disorders. Furthermore, mood-stabilizing drugs inhibit key enzymes that regulate phosphoinositide production and alter neuronal growth cone morphology in an inositol-reversible manner. Inositol is taken up by neurons from the extracellular fluid, presumably via membrane transpor...
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Phosphoinositides, synthesized from myo-inositol, play a critical role in the development of growth cones and in synaptic activity. As neurons cannot synthesize inositol, they take it up from the extracellular milieu. Here, we demonstrate that, in brain and PC12 cells, the recently identified H(+)/myo-inositol symporter HMIT is present in intracellular vesicles that are distinct from synaptic a...
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Inositol is usually classified as an essential vitamin for most animals, and is recognised as a part of the B-complex vitamins. Among all other inositol isomer forms, myo-inositol possesses biological activity. It is found in the brain, skeletal, heart, and main reproductive tissues and exists as a structural component of phosphatidylinositol in biological cell membranes. Myo-inositol, also act...
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Lithium (Li(+)) is the mood stabilizer most frequently used in the treatment of bipolar mood disorder; however, its therapeutic mechanism is unknown. In the 1980s, Berridge and colleagues proposed that Li(+) treatment acts via inhibition of IMPase (inositol monophosphatase) to deplete the cellular concentration of myo-inositol. Inositol depletion is also seen with the alternative mood stabilize...
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Purpose: The objective of this study was to evaluate the effects of myo-inositol alone or in combination with MEM vitamins on embryo development in sanjabi sheep.Materials and Methods: Sheep Cumulus Oocytes Complexes (COCs) were matured in vitro at 39ºC, in humidified 5% CO2 atmosphere for 22-24 h. There were three treatments, culture in synthetic oviductal fluid medium (treatment I), culture i...
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